Methods for suppressing allergic reactions

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United States of America Patent

PATENT NO 9868786
SERIAL NO

14111208

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Abstract

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Provided are methods for suppressing IgE and IgG-mediated allergic reactions through monoclonal antibody applications. More specifically, methods are herein provided for safe induction of rapid desensitization. Specific embodiments are herein provided for suppressing allergic reactions in a subject, including specific methods of providing a monoclonal antibody selected from the group consisting of anti-FcεRIa and anti-FcγRIIb / RIII; administering the antibody to a subject at a dose that is lower than the level required to induce shock; and administering sequentially escalating doses of the monoclonal antibody so as to induce rapid desensitization to an allergen, thereby suppressing allergic reaction in the subject.

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Patent Owner(s)

  • CHILDREN'S HOSPITAL MEDICAL CENTER;MEDIZINISCHE UNIVERSITÄT WIEN;UNIVERSITY OF CINCINNATI;THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Finkelman, Fred D Cincinnati, US 8 19
Khodoun, Marat V Cincinnati, US 5 3
Krishnamurthy, Durga Cincinnati, US 1 3
Kucuk, Zeynep (Yesim) Cincinnati, US 1 3
Strait, Richard T Mason, US 3 23

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