Targeting thymidine kinase photosensitizer and pharmaceutical composition and use for cancer treatment thereof

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United States of America Patent

PATENT NO 9872903
SERIAL NO

14434102

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Abstract

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A targeting thymidine kinase photosensitizer and pharmaceutical composition and use for cancer treatment thereof is provided, which improves the selectivity of photosensitizers to tumor cells, has better tolerance, can reach maximum blood concentration in 24 hours, has a bigger conjugated system, a longer absorption wavelength and an advantage in treating depth tumors; the wavelength area does not need to consume much energy of a light-output device and even LEDs can be used, which render PDT more practical and economical. The targeting thymidine kinase photosensitizer can be used for diagnosis and for treating prostatic carcinoma via the guidance of fluorescence imaging. The pharmaceutical composition uses a combination of a chemotherapeutic agent and the targeting thymidine kinase photosensitizer, which further improves the therapeutic effect of the PDT method, expands the application range for tumors and has good effects on metastatic tumors as well.

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Patent Owner(s)

Patent OwnerAddress
ZHEJIANG HISUN PHARMACEUTICAL CO LTDJIAOJIANG DISTRICT OF TAIZHOU CITY ZHEJIANG PROVINCE 318000 ROAD OUTSIDE NO 46 TAIZHOU CITY ZHEJIANG PROVINCE 318000

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bai, Hua Taizhou, CN 113 414
Chen, Yihui Amherst, US 40 56
Chen, Zhenliang Taizhou, CN 7 17
Pandey, Ravindra K East Amherst, US 61 1021

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