Synthesis of non-natural cofactor analogs of S-adenosyl-L-methionine using methionine adenosyltransferase

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United States of America Patent

PATENT NO 9879043
SERIAL NO

14298874

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The present disclosure relates to the synthesis of non-natural analogs of S-adenosyl-L-methionine (SAM) and/or of Se-adenosyl-L-methionine (SeAM) by reacting a methionine analog and adenosine triphosphate (ATP) in the presence of at least one methionine adenosyltransferase (MAT), and to use thereof with downstream SAM and/or SeAM utilizing enzymes. The non-natural analogs of SAM and/or SeAM have the general formula:

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Patent Owner(s)

  • UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Huber, Tyler Lexington, US 1 0
Singh, Shanteri Lexington, US 1 0
Thorson, Jon Lexington, US 10 21
Zhang, Jianjun Lexington, US 136 700

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