Inhibition of AXL/GAS6 signaling in the treatment of liver fibrosis

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United States of America Patent

PATENT NO 9879061
SERIAL NO

13714875

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Abstract

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Compositions and methods are provided for alleviating endometriosis, kidney disease, inflammatory disease and/or transplant rejection in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits AXL, MER or Tyro3 protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL, MER or Tyro3 and its ligand GAS6.

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Patent Owner(s)

  • ARAVIVE BIOLOGICS, INC.;THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cochran, Jennifer R Stanford, US 73 372
Fuh, Katherine Palo Alto, US 8 121
Giaccia, Amato J Stanford, US 28 250
Jones, Douglas Cambridge, US 60 1114
Kariolis, Mihalis Stanford, US 30 175
Miao, Yu Sunnyvale, US 23 132
O'Connor, Patrick Palo Alto, US 37 431
Rankin, Erinn Bruno Waltham, US 11 121
Tabibiazar, Raymond Menlo Park, US 14 182

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