Restoring phosphorylation of a novel PINK1 substrate to treat parkinson's disease

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United States of America Patent

PATENT NO 9879233
APP PUB NO 20150299672A1
SERIAL NO

14440746

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Abstract

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The present application relates to the field of Parkinson's disease (PD), particularly sporadic PD or PD associated with mutations in the mitochondrial kinase PINK1. A new substrate for this kinase, NdufA10, is identified herein. In Parkinson's disease, this protein is dephosphorylated, which is linked to a loss of mitochondrial membrane potential. It is shown that restoring or mimicking phosphorylation of NdufA10 restores the phenotypic defects associated with Parkinson's disease and is thus a new therapeutic paradigm.

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Patent Owner(s)

Patent OwnerAddress
KATHOLIEKE UNIVERSITEIT LEUVEN3000 LEUVEN
VIB VZW9052 GENT

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
De, Strooper Bart Leuven, BE 15 37
Morais, Epifânio Vanessa Kessel-Lo, BE 2 0
Verstreken, Patrik Blanden, BE 8 11

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