High activity mutants of cocaine esterase for cocaine hydrolysis
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United States of America Patent
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Jan 30, 2018
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app pub date -
Oct 27, 2015
filing date -
Oct 31, 2014
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Abstract
The Bacterial cocaine esterase (CocE) mutants disclosed herein each have enhanced catalytic efficiency for (−)-cocaine, as compared to CocE mutants in the prior art, including CocE mutant E172-173. The presently-disclosed subject matter further includes a pharmaceutical composition including a mutant of bacterial cocaine hydrolase, as described herein, and a suitable pharmaceutical carrier. The presently-disclosed subject matter further includes a method of treating a cocaine-induced condition comprising administering to an individual an effective amount of a mutant of bacterial cocaine hydrolase variant, as disclosed herein, to accelerate cocaine metabolism and produce biologically inactive metabolites.
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