Protein discovery using intracellular ribosome display

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United States of America Patent

PATENT NO 9879252
SERIAL NO

12671446

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Abstract

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The present invention relates to a method of identifying a protein that binds to a target molecule and has intracellular functionality. This method includes providing a construct comprising a deoxyribonucleic acid molecule encoding the protein which binds to the target molecule, with the deoxyribonucleic acid molecule being coupled to a stall sequence. A host cell is transformed with the construct and then cultured under conditions effective to form, within the host cell, a complex of the protein whose translation has been stalled, the mRNA encoding the protein, and ribosomes. The protein in the complex is in a properly folded, active form and the complex is recovered from the cell.

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Patent Owner(s)

  • CORNELL UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Contreras-Martinez, Lydia Ithaca, US 1 3
Delisa, Matthew P Ithaca, US 24 73

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