Small molecule drug conjugates

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United States of America Patent

PATENT NO 9884122
SERIAL NO

15226439

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Abstract

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A targeted therapeutic agent comprising a compound of formula I:

description='In-line Formulae' end='lead'B-L-D  (I),description='In-line Formulae' end='tail'

wherein: B is a low molecular weight binding moiety for Carbonic Anhydrase IX (CAIX); D is a drug moiety; and L is a linker group that undergoes cleavage in vivo for releasing said drug moiety in an active form. The drug moiety is suitably a cytotoxic agent for targeted delivery to cancer cells expressing CAIX. The binding moiety B suitably comprises a sulfonamidothiadiazole moiety. The binding moiety B may comprise one, two or more groups capable of binding to CAIX. The linker group suitably comprises a disulfide bond and/or a triazole group and/or a cleavable peptide group.

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Patent Owner(s)

Patent OwnerAddress
ETH ZURICH8092 ZURICH

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Decurtins, Willy Horgen, CH 7 3
Krall, Nikolaus Vienna, AT 8 1
Neri, Dario Buchs, CH 68 510
Scheuermann, Jörg Würenlos, CH 8 5
Wichert, Moreno Wangen-Nuolen, CH 7 3

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