Companion diagnostic for CDK4 inhibitors

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United States of America Patent

PATENT NO 9889135
SERIAL NO

14884329

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Abstract

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The present invention relates to the use of one or more biomarkers to evaluate the likelihood that a CDK4 inhibitor would produce an anti-cancer effect in a subject. It is based, at least in part, on the discovery that cancer treatment with a CDK4 inhibitor is more effective where treated cancer cells undergo cellular senescence rather than a transient cell cycle arrest, where cellular senescence is associated with decreased MDM2 protein level. Accordingly, in non-limiting embodiments, the present invention provides for methods, compositions, and kits for a companion diagnostic for CDK4 inhibitors, and in particular, to the use of MDM2 expression as a biomarker for the likelihood that a cancer can be successfully treated by CDK4 inhibition.

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Patent Owner(s)

  • MEMORIAL SLOAN-KETTERING CANCER CENTER

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Crago, Aimee New York, US 2 14
Dickson, Mark A New York, US 4 30
Klein, Mary Elizabeth New York, US 4 14
Koff, Andrew Westbury, US 14 209
Kovatcheva, Marta New York, US 4 14
Liu, David Elmhurst, US 259 4790
Schwartz, Gary K New York, US 11 70
Singer, Samuel New York, US 16 368

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