Genetically-modified cells comprising a modified human T cell receptor alpha constant region gene

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United States of America Patent

PATENT NO 9889161
SERIAL NO

15607059

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Disclosed herein is a genetically-modified cell comprising in its genome a modified human T cell receptor alpha constant region gene, wherein the cell has reduced cell-surface expression of the endogenous T cell receptor. The present disclosure further relates to methods for producing such a genetically-modified cell, and to methods of using such a cell for treating a disease in a subject.

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PRECISION BIOSCIENCES INC302 EAST PETTIGREW STREET DIBRELL BUILDING SUITE A-100 DURHAM NC 27701

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Antony, Jeyaraj Chapel Hill, US 17 157
Bartsevich, Victor Durham, US 42 400
Jantz, Derek Durham, US 134 763
MacLeod, Daniel T Durham, US 27 164
Nicholson, Michael G Chapel Hill, US 51 212
Smith, James Jefferson Morrisville, US 130 559

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