Retinoic acid receptor antagonists as chaperone-mediated authophagy modulators and uses thereof

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United States of America Patent

PATENT NO 9890143
SERIAL NO

15298280

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Abstract

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Compounds, compositions and methods are provided for selectively activating chaperone-mediated autophagy (CMA), protecting cells from oxidative stress, proteotoxicity and lipotoxicity, and/or antagonizing activity of retinoic acid receptor alpha (RARα) in subjects in need thereof.

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Patent Owner(s)

  • ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cuervo, Ana Maria Bronx, US 10 8
Gavathiotis, Evripidis Flushing, US 41 154
Xin, Qisheng Bronx, US 7 12

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