Mixed-mode antibody affinity separation matrix and purification method using the same, and the target molecules

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United States of America Patent

PATENT NO 9890191
SERIAL NO

14424718

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A mixed mode antibody affinity separation matrix comprises an antibody affinity ligand and a cation exchange group on a single separation matrix. According to such a matrix in the first step of a process for purifying an antibody or an Fc-containing target molecule, the antibody as the main target substance of the affinity purification can be purified at high purity, the selective separation properties of monomers can also be improved; and the burden on a subsequent impurity removal step can be reduced with respect to the removal of impurities such as aggregates.

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Patent Owner(s)

  • KANEKA CORPORATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Minakuchi, Kazunobu Takasago, JP 12 9

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