Targeted nitroxide agents

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United States of America Patent

PATENT NO 9890192
SERIAL NO

14943965

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Abstract

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Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.

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Patent Owner(s)

  • UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Frantz, Marie-Celine Seine Saint Denis, FR 10 15
Wipf, Peter Pittsburgh, US 104 458

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