Peptides based on the transmembrane domain of a toll-like receptor (TLR) for treatment of TLR-mediated diseases

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United States of America Patent

PATENT NO 9890202
SERIAL NO

13811226

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Abstract

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Peptides are provided that are capable of inhibiting cell activation mediated by a Toll-like receptor (TLR) selected from TLR 1, 2, 4 or 6, said peptide comprising a sequence consisting of, or found within, the sequence of the transmembrane domain of a TLR selected from TLR 1, 2, 4 or 6 and optionally cytoplasmic and extracellular regions flanking the transmembrane domain. These peptides as well as pharmaceutical composition comprising them are useful for the treatment of TLR-mediated disease.

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Patent Owner(s)

Patent OwnerAddress
YEDA RESEARCH AND DEVELOPMENT CO LTDREHOVOT REHOVOT CENTRAL DISTRICT

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fink, Avner Rehovot, IL 3 10
Reuven, Eliran-Moshe Rehovot, IL 2 0
Shai, Yechiel Yahud, IL 21 125
Shmuel-Galia, Liraz Rehovot, IL 1 0

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