Surface anchored light chain bait antibody display system
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United States of America Patent
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Feb 13, 2018
Issued Date -
N/A
app pub date -
May 6, 2013
filing date -
May 11, 2012
priority date (Note) -
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status (Latency Note)
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Abstract
The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. Embodiments of the invention provide a system in which a bait complexed with a monovalent antibody fragment can be captured prior to secretion in a host cell by virtue of surface displaying an antibody light chain and utilizing the covalent interaction of this light chain with the heavy chain of an antibody molecule that is co-expressed in the same host. Polypeptides, polynucleotides and host cells useful for making the antibody display system are also provided along with methods of using the system for identifying antibodies that bind specifically to an antigen of interest.
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