PRDM14 and FAM19A4, molecular diagnostic markers for HPV-induced invasive cancers and their high-grade precursor lesions

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United States of America Patent

PATENT NO 9890432
SERIAL NO

14434866

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Abstract

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The invention relates to method for detecting HPV-induced high-grade precancerous lesions and HPV-induced invasive cancers, said method comprising detection of hypermethylation in the PRDM14 and/or FAM19A4 gene in a cell whereby such hypermethylation indicates the presence of HPV-induced precursor lesions with invasive potential and HPV-induced invasive cancers. The invention further comprises the use of the PRDM14 and/or FAM19A4 gene in such a method and a testkit for the detection of PRDM14 and/or FAM19A4 methylation.

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Patent Owner(s)

  • SELF-SCREEN B.V.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Meijer, Christophorus Joannes Lambertus Maria Amsterdam, NL 9 17
Snijders, Petrus Josephus Ferdinandus Amsterdam, NL 7 15
Steenbergen, Renske Daniëla Maria Amsterdam, NL 7 4

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