Transgenic immunodeficient mouse expressing human SIRP-alpha

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United States of America Patent

PATENT NO 9894888
SERIAL NO

14388108

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Abstract

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The present invention provides a transgenic mouse which comprises a deficiency for murine T lymphocytes, B lymphocytes and NK cells, a deficiency for murine MHC class I and MHC class II molecules, and a functional xenogenic SIRPα transgene. This mouse is useful for in vivo screening of various compounds, including immuno-therapeutic agents and vaccines. The said mouse is also useful for testing the in vivo metabolism of xenobiotic compounds.

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INSTITUT PASTEUR75724 PARIS CEDEX 15

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Garcia, Sylvie Arcueil, FR 4 69
Serra-Hassoun, Malika Charenton-le-Pont, FR 2 0

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