Transgenic non-human mammal that expresses human MMP2

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United States of America Patent

PATENT NO 9894889
SERIAL NO

15103457

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A transgenic non-human mammal has a genome that includes an early-immediate enhancer of human cytomegalovirus (CMV enhancer), a β-actin promoter and the entire gene region of human matrix metalloproteinase 2 (hMMP2) disposed downstream of the promoter. The hMMP2 is systemically expressed in the transgenic non-human mammal, which thus provides a suitable animal model for studying chronic obstructive pulmonary disease and related diseases and conditions.

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MIE UNIVERSITY1577 KURIMAMACHIYA-CHO TSU-SHI 514-8507

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gabazza, Esteban C Tsu, JP 8 4
Kobayashi, Tetsu Tsu, JP 20 277
Taguchi, Osamu Tsu, JP 19 51

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