Halogenated diarylacetylenes and methods of treating cancer

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United States of America Patent

PATENT NO 9895324
SERIAL NO

14668865

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Abstract

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Halogenated diarylacetylenes, e.g., diarylacetylenes having at least one halo substituent in one aryl ring and an amine in the opposing aryl ring, can inhibit the proliferation of LS174T colon cancer cells through the inhibition of c-myc and induction of the cyclin-dependent kinase inhibitor-1 (i.e., p21(Wif1/Cip1)). Such compounds are useful as antineoplastic agents.

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Patent Owner(s)

  • UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Liu, Chunming Lexington, US 39 239
Sviripa, Vitaliy M Lexington, US 8 12
Watt, David Lexington, US 20 865
Zhang, Wen Lexington, US 358 1612

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