FGF21 derivatives and uses thereof

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United States of America Patent

PATENT NO 9895417
SERIAL NO

15643543

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Abstract

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The invention relates to a derivative of a FGF21 protein having a cysteine residue at a position corresponding to position 167, 169, 170, 171, 172, 173, 174, 175 and in particular position 180 or position 181 of mature human FGF21 and derivatives thereof having a side chain attached to this cysteine. The FGF21 derivatives of the invention display high potency towards the FGF receptors. The invention also relates to pharmaceutical compositions comprising such FGF21 derivatives and pharmaceutically acceptable excipients, as well as the medical use of the FGF21 derivatives.

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Patent Owner(s)

Patent OwnerAddress
NOVO NORDISK A/SNOVO ALLE 1 BAGSVAERD 2880

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Andersen, Birgitte Maloev, DK 24 128
Olsen, Joergen Vaerloese, DK 3 6
Sass-Oerum, Kristian Koebenhavn V, DK 11 39
Tagmose, Tina Moeller Ballerup, DK 17 88
Wieczorek, Birgit Koebenhavn N, DK 18 168

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