Chimeric OspA genes, proteins and methods of use thereof

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United States of America Patent

PATENT NO 9895434
APP PUB NO 20160235830A1
SERIAL NO

15049438

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.

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Patent Owner(s)

  • BAXALTA GMBH;BAXALTA INCORPORATED;BROOKHAVEN SCIENCE ASSOCIATES, LLC;THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Crowe, Brian A Leobendorf, AT 7 35
Dunn, John J Bellport, US 45 891
Livey, Ian Vienna, AT 11 96
Luft, Benjamin J Riverhead, US 16 151
O'Rourke, Maria Wiener Neudorf, AT 6 29
Schwendinger, Michael Neusiedl Am See, AT 11 64

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