DNA glycosylase/lyase and AP endonuclease substrates

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United States of America Patent

PATENT NO 9896719
SERIAL NO

15284065

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Abstract

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A new class of nucleic acid substrates for AP endonucleases and members of the glycosylase/lyase family of enzymes is described. Representatives of each family, the enzymes Nfo and fpg, respectively, cleave nucleic acid backbones at positions in which a base has been replaced by a linker to which a variety of label moieties may be attached. The use of these synthetic substrates embedded within oligonucleotides is of utility in a number of applications.

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Patent Owner(s)

Patent OwnerAddress
ABBOTT DIAGNOSTICS SCARBOROUGH INC10 SOUTHGATE ROAD SCARBOROUGH ME 04074

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Armes, Niall A Suffolk, GB 58 2600
Piepenburg, Olaf Essex, GB 49 1930

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