Genetically modified non-human animals and methods of use thereof

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United States of America Patent

PATENT NO 9901082
SERIAL NO

14072626

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Abstract

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Genetically modified non-human animals are provided that may be used to model human hematopoietic cell development, function, or disease. The genetically modified non-human animals comprise a nucleic acid encoding human IL-6 operably linked to an IL-6 promoter. In some instances, the genetically modified non-human animal expressing human IL-6 also expresses at least one of human M-CSF, human IL-3, human GM-CSF, human SIRPa or human TPO. In some instances, the genetically modified non-human animal is immunodeficient. In some such instances, the genetically modified non-human animal is engrafted with healthy or diseased human hematopoietic cells. Also provided are methods for using the subject genetically modified non-human animals in modeling human hematopoietic cell development, function, and/or disease, as well as reagents and kits thereof that find use in making the subject genetically modified non-human animals and/or practicing the subject methods.

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Patent Owner(s)

  • INSTITUTE FOR RESEARCH IN BIOMEDICINE (IRB);REGENERON PHARMACEUTICALS, INC.;YALE UNIVERSITY

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Borsotti, Chiara New York Bronxville, US 6 89
Dhodapkar, Madhav New Haven, US 8 93
Flavell, Richard Guilford, US 40 507
Manz, Markus G Zollikon, CH 5 89
Murphy, Andrew J Croton-on-Hudson, US 476 6186
Stevens, Sean San Diego, US 209 3555
Strowig, Till Braunschweig, DE 18 246
Yancopoulos, George D Yorktown Heights, US 239 5467

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