Non-human animals having a humanized signal-regulatory protein gene

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United States of America Patent

PATENT NO 9901083
APP PUB NO 20170265442A1
SERIAL NO

15615298

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Abstract

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Genetically modified non-human animals and methods and compositions for making and using the same are provided, wherein the genetic modification comprises a humanization of an endogenous signal-regulatory protein gene, in particular a humanization of a SIRPα gene. Genetically modified mice are described, including mice that express a human or humanized SIRPα protein from an endogenous SIRPα locus.

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Patent OwnerAddress
REGENERON PHARMACEUTICALS INC777 OLD SAW MILL RIVER ROAD TARRYTOWN NY 10591

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gurer, Cagan Chappaqua, US 128 1353
Murphy, Andrew J Croton-on-Hudson, US 476 6197
Thurston, O Gavin Briarcliff Manor, US 22 374
Varghese, Bindu Hopewell Junction, US 20 323

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