Library-based methods and compositions for introducing molecular switch functionality into protein affinity reagents

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United States of America Patent

PATENT NO 9902948
SERIAL NO

13848547

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Abstract

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Methods and compositions are disclosed for introducing molecular switch functionality into a protein affinity reagent to render its binding to a target molecule sensitive to an environmental trigger, such as pH, while maintaining binding affinity to the target molecule. Combinatorial libraries created by the method are also disclosed.

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Patent Owner(s)

Patent OwnerAddress
NORTHERN ILLINOIS RESEARCH FOUNDATIONC/O NORTHERN ILLINOIS UNIVERSITY LOWDEN HALL 301 DEKALB IL 60115

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Horn, James R Sycamore, US 2 7

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