Oligonucleotides comprising alternating segments and uses thereof

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United States of America Patent

PATENT NO 9902953
SERIAL NO

13599520

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Abstract

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The invention relates to oligonucleotides having alternating segments of sugar-modified nucleosides and 2′-deoxynucleosides, and uses thereof. The invention further related to oligonucleotides having alternating segments of sugar-modified nucleotides and 2′-deoxynucleotides, and uses thereof. Such uses include the preparation of antisense oligonucleotides and their use for the prevention or depletion of function of a target nucleic acid of interest, such as an RNA, in a system. Accordingly, and oligonucleotide of the invention is useful for therapeutic, analytical and diagnostic methods and uses, as well as component of compositions and commercial packages corresponding to such methods and uses.

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Patent Owner(s)

  • MCGILL UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Damha, Masad J St. Hubert, CA 16 155
Parniak, Michael A Pittsburg, US 11 106

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