Methods of using a vaccine composition containing synthetic adjuvant

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United States of America Patent

PATENT NO 9907845
APP PUB NO 20140341970A1
SERIAL NO

14096582

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Abstract

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Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.

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Patent Owner(s)

Patent OwnerAddress
ACCESS TO ADVANCED HEALTH INSTITUTE1616 EASTLAKE AVE E STE 400 SEATTLE WA 98102

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Carter, Darrick Seattle, US 104 1401
Reed, Steven G Bellevue, US 156 1876

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