Single-chain trail-receptor agonist proteins

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United States of America Patent

PATENT NO 9908927
SERIAL NO

14694358

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Abstract

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Provided herein are specific TRAIL receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a TRAIL-associated disease or disorder. The TRAIL receptor agonist proteins provided herein comprise three soluble TRAIL domains and an Fc fragment. The TRAIL receptor agonist proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.

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Patent OwnerAddress
APOGENIX AGIM NEUENHEIMER FELD 584 HEIDELBERG 69120

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Buchanan, Fritz G Salem, US 8 12
Gieffers, Christian Dossenheim, DE 44 87
Hill, Oliver Neckarsteinach, DE 44 94
Lappe, Susan E Riverwoods, US 6 38
Phillips, Darren C Glenview, US 2 3
Thiemann, Meinolf Schriesheim, DE 43 93

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