Biomolecular processing platform and uses thereof

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United States of America Patent

PATENT NO 9909173
SERIAL NO

14763972

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to a device comprising a biomolecular processor. Each biomolecular processor has one or more bioreactor chambers defined by a solid substrate; a support structure within each bioreactor; a cleaving enzyme immobilized to the support structure and operatively positioned within the bioreactor chamber to cleave monomer or multimer units of a biopolymer molecule operatively engaged by the cleaving enzyme; and one or more time-of-flight channels formed in the solid substrate and fluidically coupled to said one or more bioreactor chambers. Each of the time-of-flight channels have two or more sensors including at least (i) a first sensor contacting the time-of-flight channel proximate to the input end of the channel and (ii) a second sensor contacting the time-of-flight channel proximate to the output end of channel. The present invention further relates to methods of sequencing and identifying biopolymer molecules using the device.

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Patent Owner(s)

  • CORNELL UNIVERSITY;BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE;NORTHEASTERN UNIVERSITY;THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barany, Francis New York, US 96 5025
Grills, George Trumansburg, US 3 28
McCarley, Robin Prairieville, US 3 16
McKinney, Collin J Durham, US 5 81
Moldovan, Dorel Baton Rouge, US 2 14
Murphy, Michael C Baton Rouge, US 11 119
Nikitopoulos, Dimitris Baton Rouge, US 2 15
Park, Sunggook Baton Rouge, US 5 27
Podlaha-Murphy, Elizabeth J West Roxbury, US 3 17
Soper, Steven A Baton Rouge, US 15 305

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