Genetically modified mouse whose genome comprises a humanized CD274 gene

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United States of America Patent

PATENT NO 9913461
APP PUB NO 20160157469A1
SERIAL NO

14963402

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Abstract

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Non-human animals, methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of a Cluster of Differentiation 274 (CD274) gene. Such non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous CD274 gene so that said non-human animals express a Programmed cell death ligand 1 (PD-L1) polypeptide that includes a human portion and an endogenous portion (e.g., a non-human portion).

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Patent Owner(s)

  • REGENERON PHARMACEUTICALS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Burova, Elena Mount Kisco, US 22 343
Lai, Ka-Man Venus Tarrytown, US 74 1363
Murphy, Andrew J Croton-on-Hudson, US 476 6172
Tang, Yajun White Plains, US 15 25

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