Induced pacemaker and Purkinje cells from adult stem cells

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United States of America Patent

PATENT NO 9913865
APP PUB NO 20170182099A1
SERIAL NO

14980274

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Adult stem cells are reprogrammed to form pacemaker cells and Purkinje cells through the sequential activation of SHOX2>TBX5>HCN2. These Purkinje cells spontaneously surround and connect with the larger pacemaker cells, thus forming an induced sinoatrial body that produces funny current and can make cardiovascular tissues beat in a manner similar to a natural sinoatrial node.

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Patent Owner(s)

Patent OwnerAddress
INGENERON INC8205 EL RIO STREET HOUSTON TX 77054

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alt, Eckhard Houston, US 122 10707
Karimi, Tahereh Houston, US 19 3

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