Liquid pharmaceutical formulations for injection comprising thiamine pyrophosphate 1-(3-aminopropyl)-2-methyl-1H-imidazole and uses thereof

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United States of America Patent

PATENT NO 9913905
SERIAL NO

14483896

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Concentrated, low-viscosity, low-volume liquid pharmaceutical formulations of proteins have been developed. Such formulations can be rapidly and conveniently administered by subcutaneous (SC) or intramuscular (IM) injection, rather than by lengthy intravenous infusion. These formulations include low-molecular-weight and/or high-molecular-weight proteins, such as mAbs, and organophosphates. The viscosity of the formulation is significantly reduced by the addition of one or more organophosphates.

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Patent Owner(s)

  • EAGLE BIOLOGICS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Crane, Alan Waban, US 16 88
Klibanov, Alexander M Boston, US 54 1914
Langer, Robert S Newton, US 623 35600
Larson, Alyssa M Dana Point, US 12 65
Love, Kevin Boston, US 19 121
Weight, Alisha K Mill Creek, US 12 65

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