TrKA kinase inhibitors, compositions and methods thereof

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United States of America Patent

PATENT NO 9914736
SERIAL NO

15128782

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Abstract

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The present invention is directed to substituted five membered heteroaryl benzamide compounds of formula (I) (Formula (I)) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.

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Patent Owner(s)

  • MERCK SHARP & DOHME CORP.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cooke, Andrew J West Point, US 6 6
Fraley, Mark E North Wales, US 89 1006
Li, Chun Sing Shanghai, CN 43 233
Liu, Ping Westfield, US 542 8658
Mao, Qinghua Shanghai, CN 12 6
McComas, Casey C Phoenixville, US 15 17
McWherter, Melody Boyertown, US 8 12
Mitchell, Helen Richboro, US 7 10
Parker, Dann Cranford, US 7 3
Schirripa, Kathy Quakerstown, US 5 7
Stump, Craig A West Point, US 51 273
Zhang, Xu-Fang Dresher, US 11 69

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