Non-naturally occurring factor H binding proteins (fHbp) and methods of use thereof

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United States of America Patent

PATENT NO 9914756
SERIAL NO

14907228

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Abstract

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Non-naturally occurring factor H binding proteins derived from variant 3 fHbp that can elicit antibodies that are bactericidal for at least one strain of N. meningitidis, and methods of use of such proteins, are provided. In certain embodiments, a non-naturally occurring factor H binding protein (fHbp) derived from a naturally occurring variant 3 fHbp is disclosed. The non-naturally fHbp may include a substitution of the histidine at position 223 of the naturally occurring variant 3 fHbp with an amino acid selected from the group consisting of arginine, lysine, phenylalanine, tyrosine, or tryptophan, wherein the numbering of position 223 is based on the numbering of the mature fHbp ID 1. The non-naturally occurring fHbp may have a lower affinity for human factor H (fH) than fHbp ID 79.

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Patent Owner(s)

Patent OwnerAddress
CHILDREN'S HOSPITAL & RESEARCH CENTER AT OAKLAND747 52ND STREET OAKLAND CA 94609

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Beernink, Peter T Walnut Creek, US 16 54

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