Cell-permeable probes for identification and imaging of sialidases

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United States of America Patent

PATENT NO 9914956
SERIAL NO

14422310

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Abstract

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Provided herein are novel irreversible sialidase inhibitors. These compounds can be conjugated with a detectable tagging moiety such as azide-annexed biotin via CuAAC for isolation and identification of sialidases. The provided compounds and the corresponding detectable conjugates are useful for detecting sialidase-containing pathogens and imaging in situ sialidase activities under physiological conditions.

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Patent Owner(s)

  • ACADEMIA SINICA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cheng, Yih-Shyun E Taipei, TW 6 107
Fang, Jim-Min Taipei, TW 32 262
Tsai, Charng-Sheng New Taipei, TW 3 47
Wong, Chi-Huey Rancho Santa Fe, US 212 2869

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