Nucleic acid-based linkers for detecting and measuring interactions

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United States of America Patent

PATENT NO 9914958
SERIAL NO

14356282

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Abstract

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The invention provides compositions comprising nucleic acid complexes for use in monitoring binding interactions and in measuring association and/or dissociation kinetics with or without force, detecting analytes, screening aptamers, and encoding/encrypting information. In some instances, the nucleic acid complexes are double-stranded nicked nucleic acids comprising a scaffold nucleic acid hybridized to one or more oligonucleotides. In some instances, a first and/or a second oligonucleotide are linked to moieties that are known to interact with each other or which are suspected of interacting with each other.

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Patent Owner(s)

  • CHILDREN'S MEDICAL CENTER CORPORATION;PRESIDENT AND FELLOWS OF HARVARD COLLEGE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Halvorsen, Kenneth Anders Glenmont, US 11 81
Wong, Wesley Philip Cambridge, US 28 130

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