High-throughput system and method for identifying antibodies having specific antigen binding activities

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United States of America Patent

PATENT NO 9915665
APP PUB NO 20140243228A1
SERIAL NO

14141498

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Abstract

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System and methods are disclosed for identifying and isolating antibodies with specific affinity with an antigen of interest. Multiple DNA libraries encoding antibodies or their fragments are designed such that the encoded antibodies from different libraries are tagged differently. These libraries may be transformed into yeast cells. The variants of the antibodies are displayed on the surface of the yeast cells and flow cytometry may be used to sort the cells based on antigen affinity and the different tags on the antibodies. By allowing multiple libraries to be screened simultaneously, the disclosed methods help improve the efficiency of affinity.

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Patent Owner(s)

Patent OwnerAddress
ABBVIE INC1 NORTH WAUKEGAN ROAD NORTH CHICAGO IL 60064

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Benatuil, Lorenzo Northborough, US 35 205
Hsieh, Chung-Ming Newton, US 104 959
Perez, Jennifer Worcester, US 15 56

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