Protein ligand for affinity isolation matrix
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United States of America Patent
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Mar 20, 2018
Grant Date -
Jun 16, 2016
app pub date -
Sep 24, 2013
filing date -
Sep 21, 2012
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Abstract
An object of the present invention is to develop techniques to create novel engineered protein ligands that maximize the binding capacity and binding efficiency to a target molecule of affinity separation matrices on which the protein ligands are immobilized. The present invention provides protein ligands (variants) that can be immobilized on carriers in a manner shown in schematic FIG. 1(4)-(15), as well as antibody affinity separation matrices obtained by immobilizing such a protein ligand on a water-insoluble carrier. The affinity separation matrices are characterized by their excellent binding capacity and binding efficiency to a target molecule.
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