Methods of producing 7-carbon chemicals from long chain fatty acids via oxidative cleavage

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United States of America Patent

PATENT NO 9920336
SERIAL NO

14139142

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This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the fatty acid synthesis pathway and oxidative cleavage of long chain acyl-[acp] intermediates by a monooxgenase (e.g., cytochrome P450) such as that encoded by BioI from microorganisms such as Bacillus subtillis.

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  • INVISTA NORTH AMERICA S.A.R.L.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Botes, Adriana Leonora Rosedale East, GB 78 618
Chen, Changlin Ingleby Barwick, GB 34 424
Conradie, Alex Van Eck Eaglescliffe, GB 78 680
Pearlman, Paul S Thornton, US 48 592

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