Biomarkers of lung function

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United States of America Patent

PATENT NO 9945872
SERIAL NO

13541462

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Cigarette smoking is a primary determinant of chronic obstructive pulmonary disease (COPD), which is the fourth leading cause of morbidity and mortality in the United States. Unique proteins associated with COPD capable of differentiating subjects likely to experience rapid (RPD) or slow (SLW) decline in lung function have been identified using comprehensive high-throughput proteomic approaches. Thirty peptides, which mapped to 21 unique proteins, were linearly associated with annualized rates of lung function decline among smokers with COPD characterized as having rapid or slow decline and smokers without COPD. Using three different statistical approaches to assess the data, the RPD and SLW groups are differentiated by 55 peptides, which mapped to 33 unique proteins. A number of the identified peptides are proteolytic fragments of proteins that are involved in the complement and/or coagulation systems, have anti-protease activity, or metabolic functions.

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Patent Owner(s)

Patent OwnerAddress
LINEAGEN INC423 WAKARA WAY SUITE 200 SALT LAKE CITY UT 84108

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Edmiston, Jeffrey S Mechanicsville, US 1 2
Flora, Jason Richmond, US 21 283
Leppert, Mark Salt Lake City, US 15 23
McKinney, Willie J Richmond, US 3 2
Murrelle, Edward Lenn Midlothian, US 5 3
Rana, Gaurav S J B Richmond, US 1 2
van, den Oord Edwin J C G Richmond, US 4 0
Webb, Bradley Todd Richmond, US 3 2
York, Timothy Richmond, US 3 6
Zedler, Barbara K Richmond, US 6 4

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