Modified drugs for use in liposomal nanoparticles

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United States of America Patent

PATENT NO 9968554
SERIAL NO

14302537

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Abstract

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Drag derivatives are provided herein which are suitable for loading into liposomal nanoparticle carriers. In some preferred aspects, the derivatives comprise a poorly water-soluble drag derivatized with a weak-base moiety that facilitates active loading of the drag through a LN transmembrane pH or ion gradient into the aqueous interior of the LN. The weak-base moiety can optionally comprise a lipophilic domain that facilitates active loading of the drag to the inner monolayer of the liposomal membrane. Advantageously, LN formulations of the drag derivatives exhibit improved solubility, reduced toxicity, enhanced efficacy, and/or other benefits relative to the corresponding free drags.

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Patent Owner(s)

  • THE UNIVERSITY OF BRITISH COLUMBIA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bally, Marcel Bowen Island, CA 27 180
Ciufolini, Marco Vancouver, CA 23 137
Cullis, Pieter Vancouver, CA 16 453
Jigaltsev, Igor Vancouver, CA 7 8
Maurer, Norbert Vancouver, CA 20 272

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