Administration of kynurenine depleting enzymes for tumor therapy

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United States of America Patent

PATENT NO 9975959
SERIAL NO

14839293

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Abstract

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Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.

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Patent Owner(s)

  • BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Blazeck, John Austin, US 9 34
Georgiou, George Austin, US 111 1781
Lu, Wei-Cheng Austin, US 15 69
Marshall, Nicholas Austin, US 33 98
Stone, Everett Austin, US 45 226

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