Method and apparatus for measuring protein post-translational modification

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United States of America Patent

PATENT NO 9976172
SERIAL NO

15052914

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Abstract

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The present invention includes a method for analyzing reactions. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical. The solution further includes at least one controller chemical that affects the reaction between the donor chemical and the acceptor chemical. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. Another aspect of the present invention includes a method for analyzing protein function. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical. The donor chemical includes a functional group selected from ester, anhydride, imide, acyl halide, and amide. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. Yet another aspect of the present invention includes a method for analyzing protein function. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. An additional analytical method is also used to measure either the acceptor product or the donor chemical.

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Patent Owner(s)

Patent OwnerAddress
ICAGEN LLC1035 SWABIA COURT SUITE 110 NEWCASTLE N DURHAM NC 27703

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Baldwin, Sharon M Santa Fe, US 10 152
Berger, Jennifer A Los Alamos, US 15 171
Birnbaum, Eva R Los Alamos, US 18 211
Harris, Michael N Los Alamos, US 6 125
Miller, Rebecca L E Los Alamos, US 10 33
Peterson-Court, Lori J Los Alamos, US 4 13
Warner, Benjamin P Los Alamos, US 57 796

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