Photoswitchable HDAC inhibitors

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United States of America Patent

PATENT NO 9981038
SERIAL NO

14775340

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Abstract

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This invention relates to photoswitchable inhibitors of histone deacetylases and methods of using the same. Provided herein are inhibitors of HDAC having photoswitchable modulators of protein function with short thermal relaxation kinetics. The compounds are diazo compounds including a substituted or unsubstituted aryl or heteroaryl ring, wherein at least one of the rings is substituted with one or more HDAC targeting elements.

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Patent Owner(s)

Patent OwnerAddress
THE GENERAL HOSPITAL CORPORATION55 FRUIT STREET BOSTON MA 02114

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ghosh, Balaram Boston, US 13 24
Haggarty, Stephen John Dorchester, US 4 1
Hendricks, James Adam Watertown, US 5 28
Mazitschek, Ralph Belmont, US 92 1078
Reis, Surya Boston, US 3 1

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