Methods for determining protein binding specificity using peptide libraries

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United States of America Patent

PATENT NO 9988665
SERIAL NO

13208894

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Abstract

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A method for determining protein binding specificity using a screen of a peptide library is provided. The method can be used to determine binding specificity for human NAD+-dependent deacetylase SIRT1, and to identify the most efficiently deacetylated peptide sequences. The method can be also used to screen a combinatorial H4 histone N-terminal tail peptide library to examine the binding preferences of a α-phos (S1) H4 antibody toward all known possible H4 histone modification states.

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Patent Owner(s)

  • WISCONSIN ALUMNI RESEARCH FOUNDATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Denu, John M McFarland, US 6 9
Garske, Adam L Madison, US 5 108

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