Expression vector system comprising two selection markers

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United States of America Patent

PATENT NO 9994866
SERIAL NO

15356748

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Abstract

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The invention pertains to an expression vector or a combination of at least two expression vectors comprising at least

    (a) a polynucleotide encoding a product of interest or an insertion site for incorporating a polynucleotide encoding a product of interest;(b) a polynucleotide encoding a first selectable marker (sm I);(c) a polynucleotide encoding a second selectable marker (sm II), which is different from the first selectable marker (sm I),wherein the activity of the selectable marker (sm I) or (sm II) is at least partially influenced by the activity of the other selectable marker and wherein the selectable markers (sm I) and (sm II) are involved in the folate metabolism. Also provided are suitable host cells, selection methods and methods for producing polypeptides with high yield.

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Patent Owner(s)

Patent OwnerAddress
NOVARTIS AGBASEL SUI BASEL BASEL-STADT

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Jostock, Thomas Neuenburg am Rhein, DE 23 124
Knopf, Hans-Peter Schallstadt, DE 21 49

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