Polymer-polymer composite nanoassemblies and applications thereof

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United States of America Patent

PATENT NO 9999599
SERIAL NO

14421875

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Abstract

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The invention provides novel nanoscale delivery vehicles and composite nanoassemblies built from distinct nanoassembly units (e.g., block copolymer micelles and nanogels) with stoichiometric control. These intelligent composite nanoassemblies independently retain the key features of the nanoassembly units and greatly expand the potential functional features attainable based on the surface functionalization. The invention provides a novel approach to constructing nano-vehicles with controllable morphology based on combination of cooperative releasing mechanisms (e.g., redox sensitive nanogels and pH sensitive micelles). Two kinds of guests can be seperately and stably encapsulated in the composite nanocontainers, and then released sequentially under the stimulation of pH change and reduced glutathione.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF MASSACHUSETTSOFFICE OF GENERAL COUNSEL ONE BEACON STREET 31ST FLOOR BOSTON MA 02108

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Thayumanavan, Sankaran Amherst, US 34 39
Yuan, Conghui Amherst, US 10 6

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