Modulating regulatory T cell activity via Interleukin 35

Australia Patent

PATENT NO 2007298571
APP PUB NO AU-2007298571-A1
SERIAL NO

2007298571

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Abstract

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Methods for regulating T cell function in a subject, particularly regulatory T cell activity are provided. Methods of the invention include administering to a subject a therapeutically effective amount of an Interleukin 35 -specific binding agent, such as an antibody or small molecule inhibitor. The invention further provides methods for enhancing the immunogenicity of a vaccine or overcoming a suppressed immune response to a vaccine in a subject, including administering to the subject a therapeutically effective amount of an IL35-specific binding agent and administering to the subject a vaccine. In one embodiment the vaccine is a cancer vaccine.

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Patent Owner(s)

Patent OwnerAddress
ST JUDE CHILDRENS RES HOSPITALUSTENNESSEE USA

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Inventor(s)

Inventor Name Address
WORKMAN CREG -
VIGNALI DARIO -
COLLISON LAUREN -
VIGNALI KATE -

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