Methods for one-pot N-demethylation/N-acylation of morphine and tropane alkaloids

Australia Patent

PATENT NO 2008271862
APP PUB NO AU-2008271862-A1
SERIAL NO

2008271862

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The present invention relates to a one-pot method for N-demethylation and/or N-acylation of a tertiary N-methylated heterocycle such as morphine alkaloids or tropane alkaloids The method, exemplified by Scheme 1, comprises reacting said tertiary N-methylated heterocycle with an acylatmg agent in the presence of a Pd metal catalyst.

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