SYK inhibitors

China Patent

PATENT NO 107746405
APP PUB NO CN-107746405-A
SERIAL NO

201711091018

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The present disclosure relates to compounds that are Syk inhibitors and their use in the treatment of various disease states, including cancer and inflammatory disorders. In particular embodiments, the structure of the compounds is given by formula I: wherein R is1、R2、R3And R4As described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of formula I, or a pharmaceutically acceptable salt or co-crystal thereof, and methods of using these compounds and compositions to treat disorders mediated by Syk.

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